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The white faecal syndrome (WFS) of Litopenaeus vannamei has been carried out during the period of 2018 to 2019 in Vellar estuary aqua-farms, Parangipettai, South East coast of India.. The results of present study revealed that, WFS was observed in 43 days of culture on wards to up to 65 days of culture, thereafter no white faecal syndrome. The symptoms of WFS in-infected animals showed hepatopancreas and gut become white and pale yellow in colour, the infected gut in bulging and elastic nature. The performance of WFS infected ponds were showed poor growth (ADG 0.1 to 0.2g), and survival (45%) and increase in FCR (1:3.1). The incidence of WFS was high in low alkalinity (45-70ppm) and also present study showed the fresh water ponds less in WFS than the sea water ponds.